Alginate-Collagen Fibril Composite Hydrogel
نویسندگان
چکیده
منابع مشابه
Alginate-Collagen Fibril Composite Hydrogel
We report on the synthesis and the mechanical characterization of an alginate-collagen fibril composite hydrogel. Native type I collagen fibrils were used to synthesize the fibrous composite hydrogel. We characterized the mechanical properties of the fabricated fibrous hydrogel using tensile testing; rheometry and atomic force microscope (AFM)-based nanoindentation experiments. The results show...
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INTRODUCTION Alginate hydrogel is an advantageous scaffold material for cartilage tissue engineering because it encapsulates cells homogenously and provides intrinsic porosity. Blending alginate with cell adhesive molecules such as type I collagen to make composite hydrogels can further promote chondrogenenesis of mesenchymal stem cells. However, in these conventional composites, the collagen p...
متن کاملCollagen Fibril Formation
Soluble rat tail tendon collagen with intact nonhelical ends and largely free of aggregates was used to study fibril formation in vitro. The process was initiated by raising the pH and warming a cold solution of collagen. Fibril formation was monitored by turbidity and the product was examined by electron microscopy. Optimal conditions that will form fibrils similar to those observed in vivo ar...
متن کاملCollagen fibril formation.
Collagen is most abundant in animal tissues as very long fibrils with a characteristic axial periodic structure. The fibrils provide the major biomechanical scaffold for cell attachment and anchorage of macromolecules, allowing the shape and form of tissues to be defined and maintained. How the fibrils are formed from their monomeric precursors is the primary concern of this review. Collagen fi...
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................................................................................................................................... II DEDICATIONS ............................................................................................................................ III ACKNOWLEDGEMENTS ...........................................................................................................
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ژورنال
عنوان ژورنال: Materials
سال: 2015
ISSN: 1996-1944
DOI: 10.3390/ma8020799